Synergistic interaction between risk burden and genetics for atrial fibrillation development
1. In a large prospective study, risk burden and genetic predisposition acted synergistically to...
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2MM
Dementia is associated with high rates of sleep-related breathing disorders
1. In this meta-analysis, it was found that the pooled prevalence of sleep-related breathing...
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Active monitoring, prostatectomy, and radiotherapy as treatment options for localized prostate cancer result in similar prostate-cancer-mortality
1. Localized prostate cancer mortality remains similar between groups receiving prostatectomy,...
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Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors
1. There is a 71% lower risk of disease progression or death in the nirogacestat group than in the...
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Exercise improves symptoms in adults with depression
1. In this systematic review and meta-analysis, exercise had a significantly positive effect on...
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Different variants presenting with different presentations amongst children with COVID-19 infections
1. In children presenting to the emergency department (ED) with a COVID-19 infection, children...
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Exercise and caloric restriction reduce visceral fat in overweight adults
1. In this systematic review and meta-analysis, both exercise and caloric restriction were...
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#StudyGraphics: Gastric bypass surgery may reduce the risk of esophagogatric cancer in obese patients
Click to read this study in JAMA Surgery.
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Sotorasib superior to docetaxel for treatment of KRASG12C-positive non-small-cell lung cancer
1. Patients allocated to the sotorasib group reported increased progression-free survival compared...
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Age and genetics as risk factors for the development of atrial fibrillation
1. In this prospective cohort study, age was found to be the most prominent risk factor for the...
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#StudyGraphics: Atezolizumab in combination with vemurafenib and cobimetinib improve progression-free survival in patients with BRAFV600-advanced melanoma
Click to read this study in The Lancet Oncology.
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Etranacogene dezaparvovec gene therapy reduces bleeding in severe hemophilia B
1. Etranacogene dezaparvovec gene therapy was more effective than prophylactic factor IX infusion...
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Sodium bicarbonate does not prevent declining kidney function in kidney transplant recipients
1. The mean eGFR slope was comparable among patients allocated to sodium bicarbonate and placebo...
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Addition of PD-L1 inhibitor may improve outcomes in neoadjuvant therapy for esophageal cancer
1. In this phase II randomized clinical trial, treatment of patients with locally advanced...
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Ultrasound ablation of globus pallidus reduces Parkinson’s disease motor symptoms
1. In this randomized controlled trial, ultrasound ablation of the globus pallidus was associated...
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Sodium-glucose cotransporter-2 inhibitors are of intermediate or low economic value in the treatment of heart failure with preserved ejection fraction
1. Sodium-glucose cotransporter-2 inhibitors (SGLT2-I) in combination with standard of care were...
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Secukinumab reduces symptoms of moderate-to-severe hidradenitis suppurativa
1. Patients receiving secukinumab every 2-weeks showed superior clinical response rates compared...
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Black patients with pulmonary fibrosis may have worse outcomes compared to other populations
1. In this retrospective cohort study, Black patients with pulmonary fibrosis (PF) were found to...
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Prior COVID-19 infection may result in poorer sleep health
1. In this cross-sectional study, it was found that participants had lower overall sleep health...
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Bedaquiline-linezolid regimen noninferior to standard treatment for tuberculosis
1. In this randomized control trial, an eight-week bedaquiline-linezolid regimen was noninferior...
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