Elevated neutrophil-lymphocyte ratio associated with poor prognosis for head and neck cancer
1. This single-centred, observational cohort study demonstrated that among patients with head and...
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2MM
Prenatal exposure to maternal autoimmune diseases associated with increased risks of mental disorders in offspring
1. In utero exposure to any maternal autoimmune disease was associated with increased risks of...
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Radiofrequency renal denervation produces long-lasting reductions in blood pressure
1. The intervention group saw a 10 mmHg greater reduction in 24-h mean systolic blood pressure...
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Childhood insomnia symptoms may persist into adulthood
1. This study found that pre-existing sleep patterns amongst children tend to persist into...
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Reduced bleeding risk with asundexian compared to apixaban in patients with atrial fibrillation
1. Asundexian 50 mg resulted in a lower rate of bleeding compared to apixaban 5 mg twice daily. 2....
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Light exposure during sleep may alter glucose metabolism and impair cardiometabolic function
1. In this study, one night of moderate light exposure (100 lx) during sleep was associated with...
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Pembrolizumab did not show overall survival benefit in patients with microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer
1. The median overall survival for pembrolizumab versus chemotherapy was not statistically...
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Neoadjuvant nivolumab plus chemotherapy increases event-free survival in resectable non-small-cell lung cancer
1. Neoadjuvant nivolumab plus chemotherapy led to a longer event-free survival and higher...
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Periarticular liposomal bupivacaine comparable to bupivacaine hydrochloride alone
1. Among patients undergoing knee replacement, there was no difference in postoperative recovery...
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New prognostication tool predicts neurological deficits and long-term survival in patients with status epilepticus
1. In this retrospective cohort study, among 261 patients with status epilepticus, age, duration,...
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#VisualAbstract: Daprodustat noninferior to darbepoetin alfa in the treatment of anemia in patients with chronic kidney disease on incident dialysis
1. This trial demonstrated noninferiority of daprodustat to darbepoetin alfa in the treatment of...
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Abnormal findings on neonatal cranial ultrasound associated with adverse neurobehaviour outcomes in neonates born prior to 30 weeks gestation
1. White matter lesions on neonatal cranial ultrasound in neonates born prior to 30 weeks...
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Clinical response to Gram stain-guided antibiotic therapy noninferior to that of guideline-based therapy in patients with ventilator-associated pneumonia
1. Compared to guideline-based treatment, Gram stain-guided antibiotic treatment yielded...
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#VisualAbstract: Bone mineral density testing beneficial for older men receiving androgen deprivation therapy for localized or regional prostate cancer
1. Bone mineral density testing was associated with a significant decreased risk of developing...
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#VisualAbstract: Nivolumab plus chemotherapy improves progression-free survival in gastric or gastroesophageal junction cancer
Click to read this study in The Lancet Oncology.
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Initiation of targeted disease-modifying antirheumatic drugs in patients with rheumatoid arthritis not associated with reduced risk of Alzheimer disease and related dementia
1. There were no differences in the risk of Alzheimer disease and related dementia in patients...
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Fewer hospital admissions and death were seen with SARS-CoV-2 Delta (B.1.617.2) compared to Omicron (B.1.1.529) variant infections
1. The risk of hospitalization and death was lower among cases infected with Omicron variant...
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#VisualAbstract: Solid organ transplant recipients are at an increased risk of developing non-melanoma skin cancers
Click to read this study in JAMA Dermatology.
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DNA-based vaccine, ZyCoV-D, is safe and efficacious against COVID-19 infection for patients aged 12 years and older
1. Seroconversion at 84 days was greater in the ZyCoV-D group compared to placebo. 2. The...
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