Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage.

Apr 15, 2024

Experts: Chunlei Yang,Zhiwen Jiang,Xinjie Gao,Heng Yang,Jiabin Su,Ruiyuan Weng,Wei Ni,Yuxiang Gu

Subarachnoid hemorrhage (SAH) is a form of severe acute stroke with very high mortality and disability rates. Early brain injury (EBI) and delayed cerebral ischemia (DCI) contribute to the poor prognosis of patients with SAH. Currently, some researchers have started to focus on changes in amino acid metabolism that occur in brain tissues after SAH. Taurine is a sulfur-containing amino acid that is semi-essential in animals, and it plays important roles in various processes, such as neurodevelopment, osmotic pressure regulation, and membrane stabilization. In acute stroke, such as cerebral hemorrhage, taurine plays a neuroprotective role. However, the role of taurine after subarachnoid hemorrhage has rarely been reported. In the present study, we established a mouse model of SAH. We found that taurine administration effectively improved the sensorimotor function of these mice. In addition, taurine treatment alleviated sensorimotor neuron damage and reduced the proportion of apoptotic cells. Furthermore, taurine treatment enhanced the polarization of astrocytes toward the neuroprotective phenotype while inhibiting their polarization toward the neurotoxic phenotype. This study is the first to reveal the relationship between taurine and astrocyte polarization and may provide a new strategy for SAH research and clinical treatment.
© 2024. The Author(s).

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ABOUT THE EXPERTS

Chunlei Yang,Zhiwen Jiang,Xinjie Gao,Heng Yang,Jiabin Su,Ruiyuan Weng,Wei Ni,Yuxiang Gu

Chunlei Yang

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

National Center for Neurological Disorders, Shanghai, 201107, China.

Neurosurgical Institute of Fudan University, Shanghai, 201107, China.

Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200052, China.

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.

Zhiwen Jiang

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

National Center for Neurological Disorders, Shanghai, 201107, China.

Neurosurgical Institute of Fudan University, Shanghai, 201107, China.

Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200052, China.

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.

Xinjie Gao

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

National Center for Neurological Disorders, Shanghai, 201107, China.

Neurosurgical Institute of Fudan University, Shanghai, 201107, China.

Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200052, China.

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.

Heng Yang

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

National Center for Neurological Disorders, Shanghai, 201107, China.

Neurosurgical Institute of Fudan University, Shanghai, 201107, China.

Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200052, China.

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.

Jiabin Su

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

National Center for Neurological Disorders, Shanghai, 201107, China.

Neurosurgical Institute of Fudan University, Shanghai, 201107, China.

Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200052, China.

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.

Ruiyuan Weng

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

National Center for Neurological Disorders, Shanghai, 201107, China.

Neurosurgical Institute of Fudan University, Shanghai, 201107, China.

Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200052, China.

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.

Wei Ni

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. hsniwei@fudan.edu.cn.

National Center for Neurological Disorders, Shanghai, 201107, China. hsniwei@fudan.edu.cn.

Neurosurgical Institute of Fudan University, Shanghai, 201107, China. hsniwei@fudan.edu.cn.

Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200052, China. hsniwei@fudan.edu.cn.

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China. hsniwei@fudan.edu.cn.

Yuxiang Gu

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. guyuxiang1972@126.com.

National Center for Neurological Disorders, Shanghai, 201107, China. guyuxiang1972@126.com.

Neurosurgical Institute of Fudan University, Shanghai, 201107, China. guyuxiang1972@126.com.

Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, 200052, China. guyuxiang1972@126.com.

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China. guyuxiang1972@126.com.