The following is a summary of “Benefit of Complete Response to Treatment in Patients With Chronic Spontaneous Urticaria—CURE Results,” published in the December 2022 issue of Allergy and Clinical Immunology by Kolkhir, et al.
The itchy rash that comes on suddenly and lasts for weeks is called chronic spontaneous urticaria (CSU), which can be very distressing. We examine alternative techniques of assessing CSU states and publish real-world data from the international Chronic Urticaria Registry (CURE) on the correlations between CSU states and sleep impairment and other key health-related quality-of-life (HRQoL) outcomes. Baseline and 6-month follow-up (FU) CURE data were gathered. The Urticaria Control Test (UCT), the weekly Urticaria Activity Score (UAS7), and the Physician Global Assessment (PhyGA) were all used to evaluate the therapy response in the CSU states.
Dermatology Life Quality Index and Chronic Urticaria Quality-of-Life Questionnaire (CU-Q2oL) sleep domain were also evaluated, in addition to complete response to treatment (CR, UAS7 = 0), complete control of disease (CC, UCT = 16), and PhyGA equals to CR. There were a total of 2078 patients considered. Increases in UCT equal to 16, UAS7 equal to 0, and PhyGA equal to CR from baseline to FU1 and FU2 occurred in 9.8%, 17.9%, and 42.3% of patients, respectively. Better sleep and HRQoL were reported by patients whose UCT scores were higher. Having angioedema without wheals, having episodic disease, being treated with omalizumab, and being male all increased the risk of CC (P<.05).
About 16.4% (n = 77) of the 469 patients who obtained CC or CR also exhibited CC or CR on all 3 instruments. Moderate agreement (κ=0.581) was found between UCT equals 16, and UAS7 equals 0 measures, whereas agreement (κ=0.208) was found between UCT equals 16 and PhyGA equals CR. Very few patients entered the study with a CR/CC of their CSU. CSU treatment should prioritize CR because of its association with improved HRQoL and sleep quality. Patients’ UCT and UAS7 scores were more indicative of CSU status than doctors’ evaluations.
Source:
sciencedirect.com/science/article/abs/pii/S2213219822012417
