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The BRCA2 R2645G variant increases DNA binding and induces hyper-recombination.

Dec 25, 2023

ABOUT THE EXPERTS

  • Lucia Alvaro-Aranda

    Genome Instability and Cancer Predisposition Laboratory, Centro de Biologia Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid 28049, Spain.

    Ambre Petitalot

    Department of Genetics, Institut Curie, Paris 75005, France.

    PSL Research University, Paris 75005, France.

    Yasmina Djeghmoum

    Institut Curie, PSL Research University, CNRS, UMR3348, F-91405 Orsay, France.

    Paris-Saclay University CNRS, UMR3348, F-91405 Orsay, France.

    Davide Panigada

    Institut Curie, PSL Research University, CNRS, UMR3348, F-91405 Orsay, France.

    Paris-Saclay University CNRS, UMR3348, F-91405 Orsay, France.

    Jenny Kaur Singh

    Institut Curie, PSL Research University, CNRS, UMR3348, F-91405 Orsay, France.

    Paris-Saclay University CNRS, UMR3348, F-91405 Orsay, France.

    Åsa Ehlén

    Institut Curie, PSL Research University, CNRS, UMR3348, F-91405 Orsay, France.

    Paris-Saclay University CNRS, UMR3348, F-91405 Orsay, France.

    Domagoj Vugic

    Institut Curie, PSL Research University, CNRS, UMR3348, F-91405 Orsay, France.

    Paris-Saclay University CNRS, UMR3348, F-91405 Orsay, France.

    Charlotte Martin

    Institut Curie, PSL Research University, CNRS, UMR3348, F-91405 Orsay, France.

    Paris-Saclay University CNRS, UMR3348, F-91405 Orsay, France.

    Simona Miron

    Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Paris-Saclay University, 91190 Gif-sur-Yvette, France.

    Aida Contreras-Perez

    Genome Instability and Cancer Predisposition Laboratory, Centro de Biologia Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid 28049, Spain.

    Naima Nhiri

    Institut de Chimie des Substances Naturelles, Paris-Saclay University, CNRS, 91190 Gif-sur-Yvette, France.

    Virginie Boucherit

    Institut Curie, PSL Research University, CNRS, UMR3348, F-91405 Orsay, France.

    Paris-Saclay University CNRS, UMR3348, F-91405 Orsay, France.

    Philippe Lafitte

    Department of Genetics, Institut Curie, Paris 75005, France.

    PSL Research University, Paris 75005, France.

    Isaac Dumoulin

    Institut Curie, PSL Research University, CNRS, UMR3348, F-91405 Orsay, France.

    Paris-Saclay University CNRS, UMR3348, F-91405 Orsay, France.

    Etienne Rouleau

    Department of Genetics, Institut Curie, Paris 75005, France.

    PSL Research University, Paris 75005, France.

    Eric Jacquet

    Institut de Chimie des Substances Naturelles, Paris-Saclay University, CNRS, 91190 Gif-sur-Yvette, France.

    Lidia Feliubadaló

    Hereditary Cancer Program, Catalan Institute of Oncology (ICO), Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de Llobregat, Spain.

    Ciber Oncología (CIBERONC), Instituto Salud Carlos III, Madrid, Spain.

    Jesús Del Valle

    Hereditary Cancer Program, Catalan Institute of Oncology (ICO), Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de Llobregat, Spain.

    Ciber Oncología (CIBERONC), Instituto Salud Carlos III, Madrid, Spain.

    Dominique Stoppa-Lyonnet

    Department of Genetics, Institut Curie, Paris 75005, France.

    Paris-Cité University, Paris, France.

    INSERM U830, Institut Curie, Paris 75005, France.

    Sophie Zinn-Justin

    Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Paris-Saclay University, 91190 Gif-sur-Yvette, France.

    Conxi Lázaro

    Hereditary Cancer Program, Catalan Institute of Oncology (ICO), Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de Llobregat, Spain.

    Ciber Oncología (CIBERONC), Instituto Salud Carlos III, Madrid, Spain.

    Sandrine M Caputo

    Department of Genetics, Institut Curie, Paris 75005, France.

    PSL Research University, Paris 75005, France.

    Aura Carreira

    Genome Instability and Cancer Predisposition Laboratory, Centro de Biologia Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid 28049, Spain.

    Institut Curie, PSL Research University, CNRS, UMR3348, F-91405 Orsay, France.

    Paris-Saclay University CNRS, UMR3348, F-91405 Orsay, France.

REFERENCES & ADDITIONAL READING

PubMed

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