The serum tenascin C level is a marker of metabolic disorder-related inflammation affecting pancreatic cancer prognosis.

May 27, 2024

Experts: Katsuhiko Sato,Hayato Hikita,Minoru Shigekawa,Kazumasa Soma,Ryohei Yamauchi,Jihyun Sung,Seiya Kato,Yoichi Sasaki,Shinnosuke Kudo,Kenji Fukumoto,Kumiko Shirai,Kazuhiro Murai,Yuki Tahata,Teppei Yoshioka,Akira Nishio,Yoshinobu Saito,Takahiro Kodama,Yutaka Sasaki,Tomohide Tatsumi,Tetsuo Takehara

Obesity is a risk factor for pancreatic cancer development, partly due to the tissue environment of metabolic disorder-related inflammation. We aimed to detect a tissue environment marker triggered by obesity-related metabolic disorders related to pancreatic cancer progression. In murine experiments, Bl6/j mice fed a normal diet (ND) or a high-fat diet (HFD) were orthotopically injected with mPKC1, a murine-derived pancreatic cancer cell line. We used stocked sera from 140 pancreatic cancer patients for analysis and 14 colon polyp patients as a disease control. Compared with ND-fed mice, HFD-fed mice exhibited obesity, larger tumors, and worse prognoses. RNA sequencing of tumors identified tenascin C (TNC) as a candidate obesity-related serum tissue environment marker with elevated expression in tumors of HFD-fed mice. Serum TNC levels were greater in HFD-fed mice than in ND-fed mice. In pancreatic cancer patients, serum TNC levels were greater than those in controls. The TNC-high group had more metabolic disorders and greater CA19-9 levels than did the TNC-low group. There was no relationship between serum TNC levels and disease stage. Among 77 metastatic patients treated with chemotherapy, a high serum TNC concentration was an independent poor prognostic factor. Pancreatic cancer patients with high serum TNC levels experienced progression more rapidly.
© 2024. The Author(s).

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ABOUT THE EXPERTS

Katsuhiko Sato,Hayato Hikita,Minoru Shigekawa,Kazumasa Soma,Ryohei Yamauchi,Jihyun Sung,Seiya Kato,Yoichi Sasaki,Shinnosuke Kudo,Kenji Fukumoto,Kumiko Shirai,Kazuhiro Murai,Yuki Tahata,Teppei Yoshioka,Akira Nishio,Yoshinobu Saito,Takahiro Kodama,Yutaka Sasaki,Tomohide Tatsumi,Tetsuo Takehara

Katsuhiko Sato

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Hayato Hikita

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Minoru Shigekawa

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Kazumasa Soma

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Ryohei Yamauchi

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Jihyun Sung

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Seiya Kato

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Yoichi Sasaki

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Shinnosuke Kudo

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Kenji Fukumoto

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Kumiko Shirai

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Kazuhiro Murai

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Yuki Tahata

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Teppei Yoshioka

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Akira Nishio

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Yoshinobu Saito

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Takahiro Kodama

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Yutaka Sasaki

Osaka Central Hospital, 3-3-30, Umeda, Kitaku, Osaka City, Osaka, Japan.

Tomohide Tatsumi

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan.

Tetsuo Takehara

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita City, Osaka, Japan. takehara@gh.med.osaka-u.ac.jp.