Prostate cancer growth (PCa) shows racial dissimilarity in clinical and genomic qualities, and Asian patients with PCa regularly present with more forceful aggregates at determination. The capacity of TP53 to fill in as a prognostic biomarker of PCa has been very much concentrated in Western populaces. Nonetheless, no examinations to date have inspected the part of TP53 in the inconsistencies of essential hormone-guileless prostate malignancy (HNPC) among Chinese and Western populaces. We gathered prostate tumors and coordinated ordinary tissues or blood tests to perform focused cutting edge sequencing of 94 Chinese essential confined HNPC tests, and corresponded these genomic profiles with clinical results. The OncoKB information base was utilized to recognize and characterize significant changes. The abnormalities of PTEN, CDK12, and SPOP in Chinese HNPC tests were like those in the Western examples. In any case, we showed a relationship of a high recurrence of TP53 changes (21/94) with a generally higher level of modifications in the Wnt flagging pathway (15/94) in Chinese HNPC.
Reference link- https://www.nature.com/articles/s41391-020-00302-3
