Trimanganese Tetroxide Nanozyme protects Cartilage against Degeneration by Reducing Oxidative Stress in Osteoarthritis.

Apr 24, 2023

Experts: Wenhan Wang,Jiazhi Duan,Wenjun Ma,Bowei Xia,Feng Liu,Ying Kong,Boyan Li,Hang Zhao,Liang Wang,Keyi Li,Yiwei Li,Xiheng Lu,Zhichao Feng,Yuanhua Sang,Gang Li,Hao Xue,Jichuan Qiu,Hong Liu

Osteoarthritis, a chronic degenerative cartilage disease, is the leading cause of movement disorders among humans. Although the specific pathogenesis and associated mechanisms remain unclear, oxidative stress-induced metabolic imbalance in chondrocytes plays a crucial role in the occurrence and development of osteoarthritis. In this study, a trimanganese tetroxide (Mn O ) nanozyme with superoxide dismutase (SOD)-like and catalase (CAT)-like activities is designed to reduce oxidative stress-induced damage and its therapeutic effect is investigated. In vitro, Mn O nanozymes are confirmed to reprogram both the imbalance of metabolism in chondrocytes and the uncontrolled inflammatory response stimulated by hydrogen peroxide. In vivo, a cross-linked chondroitin sulfate (CS) hydrogel is designed as a substrate for Mn O nanozymes to treat osteoarthritis in mouse models. As a result, even in the early stage of OA (4 weeks), the therapeutic effect of the Mn O @CS hydrogel is observed in both cartilage metabolism and inflammation. Moreover, the Mn O @CS hydrogel maintained its therapeutic effects for at least 7 days, thus revealing a broad scope for future clinical applications. In conclusion, these results suggest that the Mn O @CS hydrogel is a potentially effective therapeutic treatment for osteoarthritis, and a novel therapeutic strategy for osteoarthritis based on nanozymes is proposed.
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

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ABOUT THE EXPERTS

Wenhan Wang,Jiazhi Duan,Wenjun Ma,Bowei Xia,Feng Liu,Ying Kong,Boyan Li,Hang Zhao,Liang Wang,Keyi Li,Yiwei Li,Xiheng Lu,Zhichao Feng,Yuanhua Sang,Gang Li,Hao Xue,Jichuan Qiu,Hong Liu

Wenhan Wang

Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, 250012, P. R. China.

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Shandong Key Laboratory of Brain Function Remodeling, Jinan, 250012, P. R. China.

Jiazhi Duan

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan, 250022, P. R. China.

Wenjun Ma

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Bowei Xia

Department of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, P. R. China.

Feng Liu

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Ying Kong

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Boyan Li

Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, 250012, P. R. China.

Shandong Key Laboratory of Brain Function Remodeling, Jinan, 250012, P. R. China.

Hang Zhao

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Liang Wang

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Keyi Li

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Yiwei Li

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Xiheng Lu

Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan, 250022, P. R. China.

Zhichao Feng

Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan, 250022, P. R. China.

Yuanhua Sang

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Gang Li

Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, 250012, P. R. China.

Shandong Key Laboratory of Brain Function Remodeling, Jinan, 250012, P. R. China.

Hao Xue

Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, 250012, P. R. China.

Shandong Key Laboratory of Brain Function Remodeling, Jinan, 250012, P. R. China.

Jichuan Qiu

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Hong Liu

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

Institute for Advanced Interdisciplinary Research (iAIR), University of Jinan, Jinan, 250022, P. R. China.