Photo Credit: Ivan-balvan
The following is a summary of “Determination of optimal cutoff value of ulcerative colitis intestinal ultrasound index to estimate endoscopic improvement in ulcerative colitis,” published in the November 2024 issue of Gastroenterology by Komatsu et al.
The ulcerative colitis intestinal ultrasound (UC-IUS) index correlates with the Mayo endoscopic subscore (MES) and helps estimate endoscopic improvement (EI) in ulcerative colitis (UC).
Researchers conducted a retrospective study to identify the optimal cutoff value of the UC-IUS index for estimating EI in UC.
They analyzed data from patients with UC who underwent IUS and endoscopy within a 15-day interval, IUS findings (bowel wall thickness, bowel blood flow, bowel wall structure, haustrations, and inflammatory fat), and MES of each colon segment (ascending, transverse, descending, and sigmoid colon) were assessed.
The results showed that the UC-IUS index was correlated with MES (r = 0.645, P<0.0001) in the test cohort (74 segments). The median UC-IUS index was 1.0 for participants with MES ≤ 1 and 6.0 for those with MES ≥ 2. A UC-IUS index 2 was the threshold for estimating MES ≤ 1. In the validation cohort (122 segments), the UC-IUS index was correlated with MES (r = 0.675, P<0.0001), with a positive predictive value (PPV) of 85.4% and a negative predictive value (NPV) of 79.0%.
They concluded that a UC-IUS index ≤ 2 can be a feasible criterion for estimating EI in UC.
Source: link.springer.com/article/10.1007/s00535-024-02172-1
