Between 2021 and 2022, the infant mortality rate rose 3% in the United States, according to the CDC. Anne K. Driscoll, PhD, and colleagues found that, in 2022, the provisional infant mortality rate for the United States was 5.60 infant deaths per 1,000 live births, which was 3% higher than the rate of 5.44 in 2021. From 2021 to 2022, there was a 3% increase in the neonatal mortality rate (from 3.49 to 3.58) and a 4% increase in the post-neonatal mortality rate (from 1.95 to 2.02). Mortality rates increased significantly among infants born to American Indian and Alaska Native non-Hispanic and White non-Hispanic women (7.46 to 9.06 and 4.36 to 4.52, respectively), as did infant mortality rates among women aged 25-29 (5.15 in 2021 to 5.37 in 2020). Mortality rates also increased among total preterm and early preterm infants and male infants, and four states—Georgia, Iowa, Missouri, and Texas— also experienced higher infant mortality rates. “Although not statistically significant, rates generally increased for most other race and Hispanic origin, maternal age, and gestational age groups, as well as for female infants, in a majority of states, and for three of the 10 leading causes of death,” Dr. Driscoll and colleagues wrote.