Dealing with newborns’ health is a delicate matter since they cannot express needs, and crying does not reflect their condition. Although newborn cries have been studied for various purposes, there is no prior research on distinguishing a certain pathology from other pathologies so far. Here, an unsophisticated framework is proposed for the study of septic newborns amid a collective of other pathologies. The cry was analyzed with music inspired and speech processing inspired features. Furthermore, neighborhood component analysis (NCA) feature selection was employed with two goals: (i) Exploring how the elements of each feature set contributed to classification outcome; (ii) investigating to what extent the feature space could be compacted. The attained results showed success of both experiments introduced in this study, with 88.66% for the decision template fusion (DTF) technique and a consistent enhancement in comparison to all feature sets in terms of accuracy and 86.22% for the NCA feature selection method by drastically downsizing the feature space from 86 elements to only 6 elements. The achieved results showed great potential for identifying a certain pathology from other pathologies that may have similar effects on the cry patterns as well as proving the success of the proposed framework.© 2024 Acoustical Society of America.