Photo Credit: Olha Pohrebniak
The following is a summary of “Clinical characteristics and impairment of activities of daily living among patients with myasthenia gravis with differing degrees of muscle weakness: a real-world study of patients in the US and five European countries,” published in the October 2024 issue of Neurology by Pesa et al.
Researchers conducted a retrospective study assessing the clinical characteristics and impairment in activities of daily living (ADL) among patients with Myasthenia gravis (MG) across different Myasthenia Gravis Foundation of America (MGFA) classifications.
They utilized data from the Adelphi Myasthenia Gravis Disease Specific Programme (DSP)TM (2020) involving 1,232 patients across the United States, France, Germany, Italy, Spain, and the United Kingdom and assessed the relationship between the MGFA classification and impairment in ADL, adjusting for sex and the Charlson Comorbidity Index (P<0.01).
The results showed that among 1,232 patients, those in MGFA class I had significantly lower ADL impairment than those in MGFA classes II and III/IV (P<0.01). However, variability existed within each class, with bulbar symptoms and shortness of breath present in some patients across all classes.
They concluded that while the MGFA classification was associated with more significant impairment in activities of daily living, individual symptoms and the impact of the disease can vary significantly among each class.
Source: bmcneurol.biomedcentral.com/articles/10.1186/s12883-024-03869-9
