Web-based cognitive screening in bipolar disorder: validation of the Internet-based Cognitive Assessment Tool in remote administration settings.

Dec 02, 2024

Experts: Jeff Zarp,Caroline Fussing Bruun,Sille Tørring Christiansen,Helle B Krogh,Oscar Vittorio Kuchinke,Christoffer Leth Bernsen,Andreas Elleby Jespersen,Jakob Eyvind Bardram,Lars Vedel Kessing,Kamilla Woznica Miskowiak

Cognitive impairments are prevalent during remission in bipolar disorder (BD), but existing cognitive screening tools are time- and resource-intensive. Digital, web-based options can facilitate detection and monitoring of these impairments across clinical and research settings.
This cross-sectional study investigated psychometric properties of the Internet-based Cognitive Assessment Tool (ICAT) when self-administered in home-based settings. Newly diagnosed, remitted outpatients with BD and healthy controls (HC) underwent cognitive testing with the standard paper-pencil tool Screen for Cognitive Impairment in Psychiatry (SCIP) in-clinic and ICAT at-home as part of baseline assessments for an intervention trial (ClinicalTrials ID: 2021-000862-14).
Data were analyzed for 31 BD patients and 29 HC. We demonstrated a strong positive correlation between at-home ICAT and in-clinic SCIP total scores within patients with BD ((29) = 0.66, < .001), which survived subsyndromal mood symptoms adjustment (partial (25) = 0.67, < .001), indicating adequate concurrent validity. There was a moderate positive correlation between ICAT and SCIP total scores across the entire sample ((54) = 0.56, < .001) and between subtest scores ( = 0.29-0.61, s ≤ .03), except the executive functions tasks ( = .1). BD patients exhibited no impaired performance compared to HC on ICAT or SCIP (s ≥ .08).
ICAT is a valid and feasible online tool for remote cognitive screening in remitted patients with BD. Web-based screening constitutes an accessible and efficient approach for implementing systematic cognitive screening in BD.

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ABOUT THE EXPERTS

Jeff Zarp,Caroline Fussing Bruun,Sille Tørring Christiansen,Helle B Krogh,Oscar Vittorio Kuchinke,Christoffer Leth Bernsen,Andreas Elleby Jespersen,Jakob Eyvind Bardram,Lars Vedel Kessing,Kamilla Woznica Miskowiak

Jeff Zarp

Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Department of Psychology, University of Copenhagen, Copenhagen, Denmark.

Caroline Fussing Bruun

Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.

Sille Tørring Christiansen

Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Department of Psychology, University of Copenhagen, Copenhagen, Denmark.

Helle B Krogh

Sexological Clinic, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.

Oscar Vittorio Kuchinke

Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Department of Psychology, University of Copenhagen, Copenhagen, Denmark.

Christoffer Leth Bernsen

Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Andreas Elleby Jespersen

Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Department of Psychology, University of Copenhagen, Copenhagen, Denmark.

Jakob Eyvind Bardram

Department of Health Technology, Digital Health Section, Technical University of Denmark, Kongens Lyngby, Denmark.

Copenhagen Center for Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.

Lars Vedel Kessing

Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.

Kamilla Woznica Miskowiak

Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Copenhagen University Hospital – Mental Health Services CPH, Copenhagen, Denmark.

Department of Psychology, University of Copenhagen, Copenhagen, Denmark.